Not all regulators are designed to operate the same way.
In the most common design, the valve between the reservoir and plenum is held open by a strong spring... typically curved washers called Belleville washers. As pressure rises in the plenum, a piston that is coupled to the valve starts to exert pressure against the spring and when the pressure is high enough, closes the valve so no more air will flow. When you fire a shot, the pressure in the plenum drops, the piston is pushed away from the valve seal, air flows in till the pressure is high enough to close the valve again.
When you make an adjustment, you're changing the distance that the piston travels and by this, the amount of spring compression before the valve closes.
Now the valve is usually just a small hole that goes through the piston so that as the piston moves, the through hole will come into contact with a PLASTIC valve seat on increasing pressure, or away from it on decreasing pressure.
So if you want MORE pressure, you're adjusting the distance the piston travels AWAY from the seat, so it will compress the spring MORE to achieve shutoff. LESS pressure requires adjusting TOWARD the seat so the spring compresses less.
So if the system is under pressure already and you try to adjust it lower, you're actually screwing the tip of the piston into the seat... which is plastic. NOT GOOD !!
Adjusting for higher pressure means screwing it AWAY from the seat so minimal damage occurs. In practice on ones like the HUMA, adjusting it higher while under pressure frequently will eventually damage the seat enough to require flipping the seat disc over or replacing it.
Hope this helps...
Bob