I've only ever had two .25s One was 45fpe and the other is 86fpe.
I shot a coyote in the brain at 50yds with the 45fpe rifle! It killed the coyote right on the spot! But, I just didn't feel like it was enough energy..., especially since I wanted to stretch my coyote shooting distance to 75yds. I've killed coyotes to 80yds with the 86fpe rifle and so long as I keep the rifle to no farther than that it is enough energy for clean, humane coyote kills.
But like you said, I use .22 for all other shooting except coyote.
It's just my opinion..., but I feel like .22 is an inherently more accurate caliber than the .25???